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KMID : 0616120200510010070
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Korean Journal of Pharmacognosy
2020 Volume.51 No. 1 p.70 ~ p.77
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Mentha arvensis Attenuates Cognitive and Memory Impairment in Scopolamine-treated Mice
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Lee Ji-Hye
Kim Hye-Jeong
Jang Gwi-Yeong
Seo Kyung-Hye
Kim Mi-Ryeo
Choi Yun-Hee
Jung Ji-Wook
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Abstract
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Mentha arvensis is used traditional medicine to treat various disorders. In the present study, M. arvensis were extracted by the solid-phase microextraction (SPME) method and analyzed by gas chromatograph-mass spectrometry (GC-MS). We investigated the protective effects and mechanisms of a M. arvensis extract on scopolamine-induced cognitive and memory impairment. Mice were orally pretreated with a M. arvensis extract or normal saline, and then behavior tests were conducted 30 min after scopolamine injection. The antioxidant capacities were analyzed by free radical scavenging (DPPH and ABTS). Acetylcholinesterase (AChE) activity were also measured using Ellman’s method ex vivo test. In behavior tests, percent of spontaneous alteration, escape latency and swimming time in target quadrant were improved by the administration of the M. arvensis extract, which suggests that the M. arvensis extract improves memory function in the scopolamine-treated mice model. In addition, M. arvensis extract showed inhibition of the free radical and AChE activity. The results of the present study suggest that the M. arvensis extract ameliorates scopolamine-induced cognitive and memory deficits through the inhibition of free radicals and AChE activity. Therefore, M. arvensis may be a promising neuroprotective agent for management of learning and memory improvements in human dementia patients.
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KEYWORD
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Mentha arvensis, Scopolamine, Memory, Essentail oil, Dementia
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